Myeloperoxidase-Derived Chlorinating Species Induce Protein Carbamylation Through Decomposition of Thiocyanate and Urea: Novel Pathways Generating Dysfunctional High-Density Lipoprotein
نویسندگان
چکیده
منابع مشابه
Myeloperoxidase-mediated dysfunctional high-density lipoprotein.
T he oxidation of lipoproteins plays an important role in atherogenesis. Most studies have focused on the oxidation of low-density lipoprotein, occurring to a significant extent in the arterial intima leading to the formation of the characteristic foam cell of the atherosclerotic plaque. 1 However, the oxidation of the proteins of high-density lipoprotein (HDL) is thought to substantially atten...
متن کاملProtein Carbamylation and Cardiovascular Disease
Carbamylation constitutes a posttranslational modification of proteins or amino acids and results from different pathways in vivo. First is the non-enzymatic reaction between isocyanic acid, a decomposition product of urea, and either the N-terminus or the ɛ-amino group of lysine residues. Isocyanic acid levels, while low in vivo, are in equilibrium with urea and are thus increased in chronic a...
متن کاملAntioxidant Effects of Vitamins C and E on the Low-Density Lipoprotein Oxidation Mediated by Myeloperoxidase
Background: Oxidative modification of low-density lipoprotein (LDL) appears to be an early step in the pathogenesis of atherosclerosis. Meanwhile, myeloperoxidase (MPO)-catalyzed reaction is one of the potent pathway for LDL oxidation in vivo. The aim of this study was to evaluate in vitro antioxidant effects of vitamins C and E on LDL oxidation mediated by MPO. Methods: MPO was isolated from f...
متن کاملStudies on the chlorinating activity of myeloperoxidase.
Two methods were utilized to demonstrate the peroxidation of chloride ion to a free species (HOCl or Cl2) by myeloperoxidase. The peroxidase caused the volatilization of radioactivity from soultions containing hydrogen peroxide and [36Cl]NaCl, and catalyzed the formation of HOCl when solutions contianing these components were passed through a Millipore filter to which the peroxidase was adsorbe...
متن کاملDysfunctional high-density lipoprotein in patients on chronic hemodialysis.
OBJECTIVES This study examined the functionality of high-density lipoprotein (HDL) in individuals with end-stage renal disease on dialysis (ESRD-HD). BACKGROUND The high rate of cardiovascular disease (CVD) in chronic kidney disease is not explained by standard risk factors, especially in patients with ESRD-HD who appear resistant to benefits of statin therapy. HDL is antiatherogenic because ...
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ژورنال
عنوان ژورنال: Antioxidants & Redox Signaling
سال: 2012
ISSN: 1523-0864,1557-7716
DOI: 10.1089/ars.2011.4403